Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease
Cerebral organoids (COs) are a self-organizing three-dimensional brain tissue mimicking the human cerebral cortex.COs are a promising new system for modelling pathological features of neurological disorders, including prion diseases.COs expressing normal prion protein (PrPC) are susceptible to prion infection when exposed to the disease isoforms of